索引于
- 打开 J 门
- Genamics 期刊搜索
- 学术钥匙
- 期刊目录
- 研究圣经
- 中国知网（CNKI）
- 西马戈
- 乌尔里希的期刊目录
- 电子期刊图书馆
- 参考搜索
- 哈姆达大学
- 亚利桑那州EBSCO
- OCLC-WorldCat
- SWB 在线目录
- 虚拟生物学图书馆 (vifabio)
- 普布隆斯
- 米亚尔
- 科学索引服务 (SIS)
- 欧洲酒吧
- 谷歌学术
分享此页面
期刊传单
抽象的
Cognitive and Memory Improvement by Duloxetine Administration in Demented Adult APP/PS1 Transgenic AD Mouse Model
Sahar Mohamed Kamal Shams El Dine
Alzheimer’s disease (AD) are often associated with memory and cognitive deficits. Effective treatment of these diseases leads to a marked improvement in the cognitive function of such patients. There is a suggestion that there is some neuroprotective properties of duloxetine, as one of the antidepressants, against dementia-associated with cognitive disorders. The present study assessed cognitively enhancing property of duloxetine in a demented adult APP/PS1 transgenic mouse model of AD. Intraperitoneal (ip) administration of a single dose of duloxetine 10 mg/kg/day before each test. This drug treatment rescued cognitive deficits in APP/PS1 mice in both cognitive tests used in this study. The results of the present study suggest that duloxetine administration can help in improvement of cognitive disorder and may inhibit any memory impairement that accompanied the pathogenesis of AD.