药物基因组学和药物蛋白质组学杂志

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Current Updates in the Genetic Polymorphisms of Human Organic Anion Transporters (OATs)

Zhen Li, Ping Hei Lam, Ling Zhu, Ke Wang and Fanfan Zhou

The Organic Anion Transporters (OATs) are a family of important membrane proteins responsible for the
absorption, distribution and excretion of a wide range of substances, including many clinically important drugs.Therefore, the function of OATs is the key determinant of drug response in human. Human genetic polymorphisms often result in the functional alternation of OATs, which in consequence, leads to the interpatient variation of therapies. In this review, we summarize the current findings about OATs, with a focus on the genetic polymorphisms and their influence on transporter function and drug performance, the information of which is critical in elucidating the essential roles of OATs played in body, as well as forming the basis of future therapeutic optimization in individuals.