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Down-Regulation of lncRNA XIST Ameliorates Lipoprotein (A) Induced Endothelial Progenitor Cell Damage via Modulating miR-126/PLK2 Axis

Xiaolei Zhang, Guoying Xu, Shizhen Wang, Pei Chen, Shanshan Chen

Recent studies have discovered that lncRNAs regulate Lipo Protein (LP) (a)-mediated Endothelial Progenitor Cells (EPCs) damage through sponging miRNAs. However, the role of XIST in EPC remains unknown. Presently, we found LP(a) treatment significantly induced apoptosis, attenuated the proliferation, migration, adhesion, angiogenesis of EPCs. While knocking down XIST or overexpression miR-126 significantly reversed LP (a) induced damage on EPCs. Moreover, forced overexpression of XIST partially offset the protective effects of overexpressing miR-126 on EPC. Mechanistically, through bioinformatics database (http://starbase.sysu.edu.cn/index.php), we found potential binding relationships between XIST and miR-126, miR-126 and PLK2. Furthermore, the dual-luciferase reporter assay and RIP experiment confirmed the targeted binding between them. Collectively, the above results confirmed that down-regulating XIST improved LP(a)-induced EPC damage by regulating the miR-126/PLK2 axis, and the XIST/miR-126/PLK2 axis exerted an essential role in regulating EPC function.