临床研究与生物伦理学杂志

抽象的

Effect of COVID-19 during Pregnancy: Studying the Maternal and Neonatal Outcomes and Assessing the Placental Changes Related to SARS-CoV-2

Surabhi Madan1*, Dharshni Ramar2, Devang Patel3, Amit Chitaliya4, Nitesh Shah5, Bhagyesh Shah6, Vipul Thakkar6, Hardik Shah7, Rashmi Chovatiya7, Pradip Dabhi5,Minesh Patel6, Amit Patel5, Nirav Bapat8, Parloop Bhatt2, Aarya Naik2, Manish Rana8, Himanshu Nayak9, Karun Dev Sharma10, Prashant Parikh11 , Bhavna Mehta11 , Bhavini Shah11

Background: Pregnant females affected with COVID-19 are reported to have poorer disease outcomes as compared to non-pregnant females of a similar age group. COVID-19 may lead to adverse changes in the placenta, which needs to be studied.

Methods: This is a case series of 63 pregnant women hospitalized with COVID-19 from May 2020 to February 2021.The primary outcomes were maternal death or complications.

Results: 63 women were studied. 83.3% of women were in the age group of 26 to 35 years. 33% women had associated comorbidities. 68.3% of women tested positive in their third trimester, 15.9% and 11% tested positive in their second and first trimesters respectively. 73% women had mild disease and 27% women required oxygen support. 3/63 women died. One woman in the second and two women in the third trimester died respectively. Histopathological examination in 13 placentae (of 19 placentae examined) was suggestive of maternal and fetal malperfusion.

Conclusion: Pregnant COVID-19 women may develop disease-related as well as obstetric complications.