致癌与突变杂志

抽象的

Lack of Association of Chronic Liver Disease in Patients with Oral Lichen Lanus

Ganesh Shreekanth Nellithady, Koneru Anila, Kattappagari Kiran Kumar and Hallikeri Kaveri

Background: Lichen Planus is a chronic inflammatory disease of oral mucosa and skin. In recent years, several reports have emphasized a possible relationship between lichen planus and liver disease. Serum glutamic oxaloacetic transaminases (SGOT), serum glutamic pyruvic transaminase (SGPT) are the most useful measures for liver cell injury. Purpose: To compare the levels of SGOT and SGPT in oral lichen planus patients and healthy controls to observe the existence of liver disease. Materials and Methods: The sample comprised 30 oral lichen planus patients and 30 healthy controls. The blood samples were collected from both the groups and subjected to biochemical analysis for SGPT and SGOT enzymes using semi automated biochemistry analyser. Statistical analysis was done using unpaired t-test (p <0.05). Results: Mean distribution of SGOT and SGPT in oral lichen planus are 23.18, 25.18 whereas in control group are 20.07, 17.53 respectively. SGOT levels showed a statistical significant difference between oral lichen planus patients and control group but not the SGPT levels. Conclusion: Our study showed no significant correlation between oral lichen planus and presence of liver disease. Although an increased level of SGOT enzymes in the absence of elevated SGPT levels were observed but this does not signify liver disease.