细菌学与寄生虫学杂志

抽象的

Nasopharyngeal Carriage of Staphylococcus aureus and its Antimicrobial Resistance Pattern among Healthy People: Systematic Review and Meta- Analysis

Ephrem Wogayehu Awulachew*, Kuma Diriba, Asrat Anja, Feven Wudneh

Background: Staphylococcus aureus nasopharyngeal colonization is common in all age group and genetic evidences have supported the causal pathway between S. aureus carriage and invasive disease. Nasopharyngeal colonization with S. aureus is dependent on a number of factors being responsible for the gain and loss of carriage. Thus, this study aimed to review global nasopharyngeal carriage of S. aureus and its antimicrobial resistance pattern among healthy people.

Methods: Electronic data bases searches of literature was conducted on PubMed, Google Scholar, Cochrane library, Embase, Hinari, Scopus, and the Directory of Open Access Journals (DOAJ). Additionally the reference lists of all identified articles were scrutinized for potentially eligible studies. Only studies published in English from January 2000 to July 2020 were considered.

Results: Globally, the estimated pooled prevalence of nasopharyngeal carriage of S. aureus using the random effects model was 22%. The highest rate of nasopharyngeal carriage of S. aureus observed in Europe 25%, followed by studies in Asia and Africa which was 22% and 21%, respectively. On the other hand, the highest nasopharyngeal carriage of S. aureus was observed in the children with age range of 6-15 years that accounted 25%. The estimated pooled global nasopharyngeal carriage of methicillin resistant S. aureus (MERSA) was 13%, while the nasopharyngeal carriage of methicillin sensitive S. aureus (MSSA) was 81%.

Conclusion: The present study showed that there is a high rate of nasopharyngeal carriage of S. aureus and MERSA among healthy people.