致癌与突变杂志

抽象的

Presentation of an Intertwined Tumor Chain from Diploid over Tetraploid towards the Aneuploid Tumors

Roland Sennerstam, Jan-Olov Strömberg, Gert Auer

The role of Tetraploidization (TPZ) in tumor progression is not clearly described as an important link from one benign tumor to a more malign tumor. In this report we will intertwine the TPZ in a chain starting with diploid and during a lot of replicative stress parameters and hypoxia under increasing genomic instability losing genetic material and move down to aneuploids tumors. To arrange this connection between DNA (DI) entities we separated all tetraploid tumors in two subgroups (1.8 ≥ DI<2.0) and to (2.0 ≥ DI<2.2), and furthermore, two aneuploid groups divided in (1.2 ≥ DI<1.4) and (1.4 ≥ DI<1.8). This rather simple higher level of resolution has opened a new way to a deeper understanding of ploidy alterations during tumor progression. In total 1253 breast cancer patients divided in five decades were included from age <40 years and up to ≥ 70s. Two connected decades (50 ≥ age<70 years) were included in mammography screening interfering with the data and improved the results. The whole data of DNA- indices in each of the four DI intervals were included within (1.2 ≥ DI<2.2). Furthermore, the genomic instability was analyzed by three increasing levels of Stemline-Scatter Index (SSI): SSI<6, SSI<15 and SSI ≤ 60 rel. units which drives the genomic instability towards higher degree of malignancy.