糖尿病病例报告

抽象的

Progression of Type 2 Diabetes Mellitus: Early Life Factors

Glucocorticoids; Malnutrition; Insulin resistance

Type 2 diabetes mellitus is multifactorial disorder with a complicated Aetiology that includes genetic, epigenetic, and environmental aspects. In recent years, evidence from both human and animal models revealed early life variables to adult diabetes risk programming. Organ development is critical during the foetal and neonatal phases. Many maternal factors during pregnancy, including malnutrition, health (hyperglycemia and obesity), lifestyle (smoking, drinking, and a junk food diet), hormone administration, and even stress, may contribute to the risk of diabetes in infants later in life. Catch-up growth, lactation, glucocorticoids, and stress have all been implicated in the development of insulin resistance or T2DM in neonates.