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Role Of Advanced Glycation End Products (Ages) And Oxidative Stress In The Failure Of Dental Implants

Hafiza sobia ramzan*,Min Guo,Lin Luo,Junado Zhang,Mingli Liu

Introduction: In the last decade dental implant has become crucial beneficial modalities. Many clinical dental implant systems have been established which can be used as the individual form of therapy or it may function together with other dental treatment methods. In this study we highlighted the role of AGEs and oxidative stress in terms of lipid peroxidation (TBARS) in the progression of periimplantitis and in the failure of dental implants.
Material and Methods: In this study we selected three groups for the investigation of TBARS and AGEs. The data consist of 10 subjects (7 M/3 F) aged between 40-60 years (average 50.0 - 4.6). Teeth were extracted and then put in PBS solution before dry freezing at −80 degree C. Also collect the saliva of patients and also from healthy individual for the study of TBARS.
Results: The statistical analysis for oxidative stress and advanced glycation end product were performed using software SPSS (Version 17.0). The statistical difference in terms of lipid peroxidation (TBARS) and AGEs shows a significant difference between groups. This shows that increase in TBARS in saliva could lead to higher oxidative stress levels in periimplantitis and periodontitis groups than in healthy group. This difference can be explained on the basis of one-way ANOVA with post-hoc Bonferroni correction due to the small sample size. The level of significance was set at p < 0.05 for all tests. Results are expressed as mean absorbance value.
Conclusion: According to our study, periimplantitis as a multifactorial disease, in which glycation and oxidative stress play a role in terms of etiology and severity. This hypothesis could lead to new therapeutic strategies in periimplantitis, using antioxidant approach in addition to conventional treatments.