心血管药理学：开放获取

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Antihyperlipidemic Effect of Solanum incanum on Alloxan Induced Diabetic Wistar Albino Rats

Tsenum JL

The effect of orally administered aqueous fruit extract of Solanum incanum on serum lipid profile of Wistar Albino rats were determined. Twelve male and female Wistar Albino rats were randomly assigned into four groups of three rats each, following acclimatization to laboratory and handling conditions. Diabetes was induced with a single dose of alloxan (120 mg/kg) body weight and plasma glucose was taken 72 h after induction to confirm diabetes. The normal control was not induced. Animals in group a (normal control) and B (diabetic) were administered 0.5 ml of normal saline respectively. Group C was administered with 10 mg/kg weight of glibenclamide and group D was administered 500 mg/kg body weight of aqueous Solanum incanum extract. Extract administration lasted for fourteen days. Water and feeds were allowed ad libitum. After the two weeks treatment with the plant extract, blood samples were collected by cardiac puncture for lipid profile analysis by standard methods and enzyme kits. At the end of week two, the lipid profile of all groups were significantly different. The result on lipid profile showed that the extract treated group was significantly lower (P>0.05) in TC, TAG and VLDL as compared to control but significantly higher (P<0.05) in HDL and LDL as compared to diabetic control. The glibenclamide treated group was significantly lower (P>0.05) in TAG, I-ID L, and VLDL as compared to the diabetic control but significantly higher (P<0.05) in TC and LDL as compared to diabetic control. However, the extract was observed to have a high significant level of TC, TG, HDL, LDL and VLDL compared to the Normal control. Result on weight showed a significant difference at week and week 2. Antihypercholesterolemic and antihypertriglyceridemic effect were observed in this result. Results suggest that Solanum incanum has a hypolipidemic effect and therefore makes it beneficial in the dietary management of cardiovascular complications associated with diabetes and that its consumptions are safe for humans.