干细胞研究与治疗杂志

抽象的

Autologous Bone Marrow Derived Mononuclear Cell Therapy for Vascular Dementia

Sharma A, Badhe P, Gokulchandran N, Kulkarni P, Sane H, Lohia M, Avhad V and Shetty A

Background: Vascular dementia affects a broad spectrum of patients with various manifestations of cognitive decline, which are attributed to cerebral or cardiovascular disease. Laboratory studies have shown that transplanted bone marrow stem cells improve neurological diseases of the central nervous system by generating neural cells or myelin-producing oligodendroglial cells and enhancing neural plasticity. But till now, there has been lack of objective data in the form of investigational findings providing evidence for clinical improvements.

Method: We present a case of a 61 year old woman diagnosed with vascular dementia, who was administered autologous bone marrow derived mononuclear cells, intrathecally.

Result: Even after follow up of 2 years she showed sustained significant clinical improvements recorded by MMSE and FIM along with corroborating changes in PET CT scan of brain showing significantly improved metabolic activity.

Conclusion: Thus, demonstrating objective evidence showing benefits of neuroregeneration rehabilitation therapy in vascular dementia.