干细胞研究与治疗杂志

抽象的

Autologous Peripheral Blood Stem Cells Increase the Telomere Length in Patient: A Case Report of 13 Patients

Ciro Gargiulo, Van H Pham, Kieu CD Nguyen, Vo LH Trieu, Thao H Duy, Kenji Abe, Sergey Aityan and Melvin Shiffman

Telomere dysfunction, which leads to genomic instability, is assumed to play a major role in the development of degenerative diseases as Cancer, Multiple Sclerosis (MS), Amyotrophic Lateral Sclerosis (ALC), Alzheimer’s Disease (AD), dementia and diabetes. However, the few epidemiologic studies that assessed the relationship between telomere length in blood cells and autologous peripheral blood stem cells (PB-SCs) have been quite erratic. Cell senescence process, still remains an exciting biological process that is characterized by important structural and morphological changes that involves deviations and alterations in nuclear structure, DNA activity in protein processing and metabolism, and apoptosis resistance. The associations between telomere length from peripheral blood leucocytes before and after infusion with autologous PB-SCs were examined in 13 case studies that were conducted at our facility. Using value range from 1.5 Kb to >20 Kb as a cut point, patients showed a significant increase of telomere length compared before the infusion of autologous PB-SCs. Meanwhile, there was a substantial improvement in terms of general health such as sleeping, attention, vitality, memory and sexual activity with a significant difference in the quality of life. Overall telomere length from blood was significantly associated with the injection of autologous PB-SCs and as far as 6 months after the injection.