老年学与老年病学研究

抽象的

Changes in Chromatin Structure along Aging

Alberto da Silva Moraes

In a world with an increasing aging population, a proper understanding of the biology of the aging process could be of economic and social significance for governments, in order to guarantee a long but productive life for the elderly. In this regard, studies about the relationship between changes in chromatin organization and aging are pivotal, since it has been widely accepted that the aging process can be genetically driven. Several studies have shown that aging is associated with changes in gene expression and chromatin structure, and that in many cases, including diseases; such phenotypes can be pharmacologically altered in order to reestablish homeostasis. Therefore, the objective of this review was to analyze what has been published in this subject from a historical perspective, and to discuss what can be concluded from those results with its impact in human health.