Tanya Kesar*
Diabetes Mellitus is a multi-factorial chronic health disorder that influences a considerable portion of the population and the number of diabetes patient is predicted to rise, as stated by the World Health Organization (WHO). Because Type-2 Diabetes Mellitus (T2DM) affects the vast diabetic patients in the majority (roughly 90%-95%) and mono target treatment frequently fails to regulate blood glucose levels and associated comorbidities. The review focuses on the major systems that are directly related to T2DM or diabetic comorbidities. The glucagon and incretin systems, as well as the peroxisome proliferation activated receptors, are all considered agonists. Aldose reductase and tyrosine phosphatase 1B inhibitors, as well as sodium glucose transporters 1 and 2, are considered. Furthermore, several phytocomplexes are explored with a vision to multiple methods for Type 2 Diabetes Mellitus (T2DM).