索引于
- 打开 J 门
- Genamics 期刊搜索
- 学术钥匙
- 期刊目录
- 中国知网（CNKI）
- 乌尔里希的期刊目录
- 参考搜索
- 哈姆达大学
- 亚利桑那州EBSCO
- 期刊摘要索引目录
- OCLC-WorldCat
- 普布隆斯
- 日内瓦医学教育与研究基金会
- 欧洲酒吧
- 谷歌学术
分享此页面
期刊传单
抽象的
Combined Jellyfish Collagen Type II, Human Stem Cells and Tgf-β3 as a Therapeutic Implant for Cartilage Repair
Marion Pugliano, Xavier Vanbellinghen, Pascale Schwinté, Nadia Benkirane-Jessel and Laetitia Keller
Background: The limitations associated to current therapies for articular cartilage repair led us to develop new strategies of applicable active therapeutic materials. Human mesenchymal stem cells from bone marrow are promising relevant cell sources for cell therapy and regenerative medicine, in particular for cartilage repair. Recently, a new source of non-mammalian collagen type II emerged and represents a promising tool for cartilage tissue engineering.
Methods: To develop a new therapeutic implant for cartilage repair, we combined (i) jellyfish collagen type II as an implant; (ii) active nanoreservoirs of growth factors (TGF-β3); (iii) adult human mesenchymal stem cells derived from bone marrow.
Results: Our results indicated clearly that (i) the jellyfish collagen type II implant leads to chondrogenic differentiation of mesenchymal stem cells; (ii) the combined implant and active therapeutic TGF-β3 as nanoreservoirs lead to chondrogenic gene expression and cartilage differentiation.
Conclusion: We reported here a new stem cell - based therapeutic active implant for cartilage repair. This approach combines jellyfish collagen type II, human stem cells and TGF-β3 as a therapeutic implant to improve cartilage differentiation and repair.