干细胞研究与治疗杂志

抽象的

Complex Treatment of the Patients with Cerebral Palsy Using Fetal Stem Cells

Nataliia Sych, Mariya Klunnyk, Iryna Matiyashchuk, Mariya Demchuk, Olena Ivankova, Andriy Sinelnyk, Marina Skalozub and Khrystyna Sorochunska

Objective: The aim of this study was to examine fetal stem cells (FSCs) treatment safety and efficacy in complex therapy for cerebral palsy (CP) children. We studied clinical, neurological, and laboratory changes in CP patients before and after FSCs therapy.
Materials and methods: 11 children diagnosed with CP were under observation in Cell Therapy Center EmCell including 6 boys aged from 2 to 13 years, whose mean age was 4.23 ± 0.24 yrs. and 5 girls aged from 2.5 to 12 years with mean age which constituted 3.92 ± 0.15 yrs. The patients were allocated to the Main Group (MG) who along with standard treatment received FSCs. Control group (CG) included 9 patients suffering from CP who underwent treatment solely with inclusion of conventional methods and consisted of 4 males (aged from 3 to 14 yrs. whose average age made up 4.01 ± 0.12 yrs.) and 5 females in age from 3 to 15 yrs. with mean age by 3.87 ± 0.18 yrs. FSCs were administered as a complex therapy for the patients with CP and the data of clinical and laboratory investigations were analyzed during the whole study period.
Results: It has been identified that patients who were administered treatment by use of FSCs revealed improvements of their immune status.
Conclusion: FSCs use in complex treatment of patients with CP stabilizes disease compensation and leads to improvement of immune blood findings.