生物等效性和生物利用度杂志

抽象的

Design and Evaluation of Wubei Gastr- Effervescent Tablet

Yan R

Objective: A new solid preparation with instant effects like powder preparation was developed.
Introduction: Its instant dispersion results from a small amount of alkaline ingredients which would react with gastric acid in stomach to produce gas causing instant disintegration.
Methodology: According to relative specification in Chinese Pharmacopoeia, prescription was optimized.The tablet and the powders were administered to beagle dogs for the double cycle cross experiment. The plasma of the dogs was measured by LC-MS/MS and was compared with each other.
Result: The in vivo studies demonstrated that the Wubeigastr-effervescent tablet showed bio-equiavailability with traditional Wubei powder. This formulation could be applied to some liquid preparations without reducing their fastness of effects.