临床与实验药理学杂志

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Drug Tolerance in Pharmacology

Mario Giorgi

When addressing drug abuse and the use of prescription drugs such as opioid painkillers, it is important to consider the significance of the words tolerance, dependency, and addiction. Unfortunately, these words are sometimes misused by both practitioners and laymen, contributing to the misguided assumption that tolerance, dependency, and addiction are just distinct names for the same thing. Knowing the difference between these words, however, will result in a clearer understanding of the risks of substance addiction. The most noticeable difference between both terms is that the physical effects of drug use relate to tolerance and dependency.