心血管药理学：开放获取

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Effects of an Acute Exercise on Endothelium Function in Athletics Young Subjects: A Case Control Study

Mohamed Sami Zguira, Ibtissem Khouaja, Firas Zghal, Hamdi Zguira, Haythem Debbabi, Bernard Saiag and Zouhair Tabka

Aim: to investigate vascular reactivity on forearm skin blood flow (FSBF) in response to iontophoresis of acetylcholine (ACh) after an acute exercise. Materials and method: 49 healthy male subjects 29 trained and 20 sedentary (recruited according to their oxygen consumption) participated in this case control study (mean age: 15 ± 1 year). Incremental exercise testing was performed by means of an individualized and personalized exercise test protocol. FSBF was measured before and after exercise using a laser Doppler flowmeter in response to local iontophoresis of a cumulative dose of ACh. Results: Although groups were not different in age, height or body mass index, weight, resting heart rate, maximum oxygen consumption was significantly different (sedentary 40.05 ± 4.53 and trained 51.65 ± 5.76 ml.min-1. kg-1) (p<0.05; p<0.001; p<0.001, respectively). The mean response of FSBF to ACh was significantly increased after incremental exercise in the two groups (349%). Maximal FSBF response to ACh was significantly greater in trained (987% ± 78) than in sedentary (638% ± 42) (p=0.001) after a single acute exercise. Conclusion: Response of FSBF to ACh-induced endothelium dependent relaxation was affected by the level of training whether before or after an acute exercise.