过敏与治疗杂志

抽象的

Effects of Persistent Allergic Rhinitis on Spirometric Parameters

Majid Jafari

Background: Allergic rhinitis (AR) is an inflammatory process due to allergens. The relation between AR and inflammation of lower airways is documented. However, AR is considered as the strong risk factor for the onset of asthma in adults. Methods: This prospective cross sectional study carried out on 126 patients with perennial allergic rhinitis (PAR). Clinical examination, skin prick test and spirometry maneuver were performed in all patients. Results: Our results showed that there is a significant difference between forced expiratory flow at 25% and 75% of the pulmonary volume (FEF 25.75). <80% of the predicted for PAR (P=0.003). There were no significant differences among patients with forced vital capacity (FVC)<80% of predicted and forced expiratory volume in the first second( FEV1 )<80% of the predicted, for PAR respectively (P>0.05, P=0.08). Furthermore, in patients who were sensitive to indoor allergens, FEF25-75<80% of the predicted was more impaired (P=0.003). There was a negative correlation between FEF25-75 and the duration of disease (r=-0.13). Conclusion: This study highlights some risk factors such as the duration of PAR, age, indoor allergens and FEF25-75 as a marker of early bronchial involvement in patients with moderate-to severe and PAR alone.