微生物与生化技术杂志

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Efficacy of CurvicTM to Boost Immunity in the Quarantine Patients of COVID-19: An Open Labelled Study

Yogesh Dound, Samadhan Patil, Yogita Gaikwad, Shrikant Suryavanshi, Rajesh Sehgal, Pranav Patel

Background: COVID-19 outbreak is a global threat, with lack of vaccines and antiviral medicine exaggerating the issue further. CDC recommends maintenance of personal hygiene as a modality to reduce chances of infection. Yet, another way is by improving the immunity. Viral infections are depended on body’s natural defenses. Authors of current paper have developed formulation containing natural ingredients viz. Curcumin, Vitamin C, Vitamin K2-7 L-Selenomethionine and Zinc based on results of in-silico studies for activity against SARS-CoV-2’s Mpro Protein.

Objectives: To evaluate role of Curvic^TM to boost immunity in quarantined patients of COVID-19 and its tolerability.

Study design: In an open-labelled study, 30 patients quarantined due to COVID-19 were administered CurvicTM tablets twice daily for 14 days. They were analysed on basis of VAS score for cough and respiratory distress, SF-36 Questionnaire and laboratory investigations.

Results: Within 48 hours, temperature reduced considerably to afebrile level and remained afebrile till end of study. Average VAS score reduced from 6-7 at baseline to 0-1 within 14 days. The high levels of serum Interleukin-6 and Homocysteine at baseline dropped considerably within 14 days. Body pain experienced by 20 patients had reduced significantly and the energy levels along with health were improved in all the patients, thereby leading to improved quality of life in all patients.

Conclusion: Curvic^TM has shown to be useful in improving the immunity of the quarantined patients of COVID-19, within 48 hours of starting treatment. Curvic^TM was well tolerated without any side effects in any of the patients treated.