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Erythrocytes Microvesciculations in Health and Diseases

Ugochukwu Maluze

Heterogeneous mixture of vesicular organelle-like structures (microvesicles) is emitted by many cell sources into their surroundings, including blood and body fluids. Microvesicles are small membrane-enclosed sacs, whose size varies from 0.1-1nm; and they are thought to be shed from a variety of cell types, constitutively when stimulated by calcium activation signal . They seem to enhance the potential information transfer between cell types, displaying a large number of proteins and lipids as membrane constituents and as components of the vesicular content. Their isolation and analysis from blood samples have the potential to provide information about state and progression of malignancy and should prove of great clinical importance as biomarkers for a variety of disease states. They are implicated in normal, physiological and pathological conditions and their potential to serve as indicators in the diagnosis, prognosis and surveillance of a variety of health conditions, have indicated the magnitude of interest in this structures.