临床研究与生物伦理学杂志

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Ethical Issues in Genome Editing using Crispr/Cas9 System

Rodriguez E

This article reviews ethical issues related to genome editing using CRISPR/Cas9 system. The use of CRISPR/ cas9 revives many previous social and ethical issues with humans, other organisms and the environment, such as taking into account the non-maleficence principle in risk assessment, genome editing in germline, safety issues to avoid ecological impairment or the possible use of the technique for genetic enhancement. The new issue is the relatively simple construction and low cost of CRISPR/Cas9 for genome editing, with the possibility of multiple purposes. A public dialogue over the social, ethical and legal implications with the regulatory needs of the system is necessary.