生物等效性和生物利用度杂志

抽象的

Evaluation of the Anaesthetic Efficacy of 4% Articaine with 1:200000 Epinephrine Versus 2% Lignocaine with 1:200000 Epinephrine in Simple Extractions of Mandibular Posterior Teeth

Kashyap V, Rath R and Tevatia S

Background: The aim of the study was to evaluate the anaesthetic efficacy of 4% articaine hydrochloride with epinephrine/adrenaline 1:200000 versus 2% lignocaine hydrochloride with epinephrine/adrenaline 1:200000 in extractions of permanent mandibular posterior teeth.

Materials and methods: One hundred (100) patients were selected for the study in the Department of Oral and Maxillofacial Surgery and Implantology. Patients were equally but randomly divided into two different groups: i) Group 1-4% articaine solution; ii) Group 2-2% lignocaine solution, both with equal concentration of epinephrine (1:200000). Standardized clinical parameters included the Visual Analogue Scale (VAS) score for each, Pain on injection, Intraoperative Pain, Onset of anaesthesia, Duration of anaesthesia, Need of reanaesthesia.

Results: On statistical evaluation of the values obtained for each patient, it was observed that Group I (4% articaine with 1:200000 epinephrine) demonstrated low pain on injection, early onset of anaesthesia (shorter latency), low intraoperative pain and reasonable duration of soft tissue anaesthesia compared to Group II (2% lignocaine with 1:200000 epinephrine) that demonstrated slow onset, more intraoperative pain and minimally longer duration of soft tissue anaesthesia.

Conclusion: it can be stated that Septanest (4% articaine hydrochloride with 1:2000000 epinephrine) may be preferred to Xylocaine (2% lignocaine hydrochloride with 1:2000000 epinephrine) in simple minor oral surgical procedures.