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Expression of NUP62 in the Development of Ovarian Cancer
Chen Yong, Chen Hongyu, Huang Shirong, Fan Xiangqun
Objective: This study aims at exploring the relationship between the universal differentially expressed genes and the development of ovarian cancer, and then we established a biological molecular model for the further biological study.
Methods: We selected the universal different expression gene, which have not yet been studied and with more than 60% coverage based on the 69 pairs of matched ovarian cancer and normal expression profiles samples with the directed network, and then analyzing the multidimensional data of NUP62 and miRNA-495.
Results: We found that mir-495, which target NUP62, was lower in patients with ovarian cancer.
Conclusion: The universal different expression of NUP62 is relevant to proliferation and apoptosis in ovarian cancer.