脑部疾病与治疗

抽象的

Gabapentin in Treatment of Two Parkinson

Zheng-Xiang Hu

Background: Pain is one of the most common and disabling non-motor symptoms in Parkinson’s disease (PD), 85%
of individuals in early/moderate PD stages have pain, and the most reported type of pain was pain around joints
(81.5%). Compared with motor symptoms, pain causes more problems to the quality of life in PD patients. However,
effective pharmacological treatment for PD pain remains poor. There are few reports about long-term use of
gabapentin (GBP) in the treatment of PD pain.
Case: We present two cases of PD, case 1 developed severe pain around the joints all over the body, case 2 developed
moderate pain around her temporomandibular joints. Both patients derived benefit from long-term using of GBP
with no adverse effect.
Conclusion: PD pain is a very difficult clinical problem to deal with, we think GBP can be the choice of some
patients: with female sex, and PD pain with dyskinesia, and especially in moderate/advanced PD stages.