生物等效性和生物利用度杂志

抽象的

Improving Melatonin Delivery Within the Eye

Alkozi HA and Pintor J

Melatonin is a neurohormone synthesized in the pineal gland as well as in other organs and it plays an important role in many ocular functions, as it is synthesized in numerous eye structures. Melatonin can reduce the intraocular pressure and to serves as an antioxidant preventing against free radicals, hence cataract formation as well as retinal damage due to glaucoma, among other functions. Ocular pharmacology is a challenging field giving the difficulties of drug delivery inside the eye due to its low bioavailability. In this sense, the present brief commentary is summarizing the latest advances in non-invasive ocular drug delivery focused on the effect of melatonin in different ocular diseases.