生物分子研究与治疗杂志

抽象的

桑寄生是治疗乳腺癌化疗引起的囊肿和口腔炎症的替代药物

阿里·阿瓦德·哈穆德·阿勒杰布里

天然产物作为新型药物的来源仍然很重要，因为与合成药物相比，这些药物不需要复杂的仪器、资源廉价、毒性较小、细菌不会对其产生抗药性。然而，天然产物在另外三个发现领域仍将发挥重要作用：它们是生物技术生产的目标、作为具有新化学结构的新先导化合物的来源以及作为从传统民间医学体系中分离出来的有用治疗的有效成分。它是药物开发的无限资源、新的化学类型和药效团，以及用于扩增成有效药物的支架，用于治疗多种疾病和其他有价值的生物活性剂。尽管合成产品因其生产成本低、时间效率高、质量控制简单、监管严格和见效快而越来越受欢迎，但它们的安全性和有效性始终存在疑问，导致发展中国家超过 80% 的总人口依赖天然产品，因为天然产品的安全性和有效性经过了时间的考验。

 

天然产物将继续作为药物来源发挥极其重要的作用。除了作为药物实体直接用于医疗的天然产物外，许多其他天然产物还可作为化学模型或模板，用于设计、合成和半合成用于治疗人类疾病的新型物质。尽管现在有一些新药物发现方法，如组合化学和基于计算机的分子建模设计，而且许多药物都是通过合成化学制成的，但它们都无法取代天然产物在药物发现和开发中的重要作用，因为大多数合成化学品的核心结构或骨架都是基于天然产物的。

 

The herb Loranthus Europaeus leaves and fruits was used in Iraq traditional medicine for treatment of inflammation, tumor and antimicrobial infection. For these reasons we tried to use the phytochemical and pharmacological studies to approache to their bioactive products as a new source for medicine. Loranthus is a genus of parasitic plants that grow on the branches of woody trees. It belongs to the family Lo-ranthaceae (the showy mistletoe family) and this genus has 1253 species. LE is a hemi-parasite mistletoe, it is a deciduous plant (flower are produced in May and June) with dull brown twinges, the fruit is yellow roundish berry, which remain sticky even after dried, the fruits ripen in late autumn and gradually fall off in late winter, the plant grows vigorously on aging trees mostly on branches of oak, and chestnut as host trees and once established, the mistletoe take minerals and water from the host tree, and block sunlight through its dense foliage, the most important vectors of yellow mistletoe are birds. LE is widely distributed in south-west Europe, south Russia, Anatolia, Iran and Iraq. In Iraq, LE distri-buted in the north of country especially in Ammadia, Roundoze and Sulymania.

 

LE had a known importance in Iraqi folk medicine for long time ago, for treating boils and abscesses, where a dry fruit used in form of poultice after mastication and moisture in the mouth, it is claimed that the poultice cause maturation and acceleration in the drain of pus from the boils, however the mechanism of action was un-known, until 2006, a study from Iraq done to evaluate the anti-inflammatory effect of the plant in animals, which explained the effect of LE oil extract in pyogenic inflammation and concluded that the oil extract may act as immunomodulator during bacterial infection and may contain substance act as a chemotactic agent for neutro-phile and promote macrophage activity. 

 

Many of these compound have a biological activities such as antihypertensive and anti-diabetic effect of L. bengwensis, and antiviral activity of L. parasiticus. Loranthus europaeus is one species of Lorantheceae, and many studies showed that LE contain many bio-logical compounds including: Flavonoids (kaempherol, quercetin and rutin), alkaloids, glycosides, carbohydrate, aldehyde, ketones, protein, polysaccharide, terpenes (monoterpens and triterpenes ), phenolic acid (caffeic and gallic acid), lipid include Palmitic acid, paraffin C30H62 and wax alcohol and sugar

 

Methods:

 

The extraction of active constituent of loranthus Europaeus (flavonoids terpenoids and alkaloids) by using chromatography method using a thimble of suxlet with different organic solvents. The ethylacetate extract contain flavonoid which contain qurcitin and quercitrin.                                 The active ingredient mixture of LE leaves extract have used as mouth wash for 10 ladies different age have breast cancer and under treatment with chemotherapy.

 

Result:

 

我们发现，从 LE 中提取的生物活性物质用作漱口水可以治愈这些女士的口腔炎症。此外，10 名不同性别的人抱怨他们的一颗牙齿上附着有囊肿，用不同类型的抗生素治疗没有反应，但当给予含有这种 LE 生物活性剂的抗生素时，囊肿完全治愈，不需要手术，这使得其中一种或多种（槲皮素和槲皮苷）活性剂的存在成为可能，它们作为抗生素的正纳米载体直接进入囊肿并治愈囊肿。