药物基因组学和药物蛋白质组学杂志

抽象的

Non-Coding RNAs: A Dynamic and Complex Network of Gene Regulation

Munshi A, Mohan V and Ahuja YR

It has been estimated that less than two percent of the mammalian genome encodes proteins, rest of the genome which was earlier considered as junk DNA is the treasure trove of non-coding RNAs (ncRNAs). Many ncRNAs have now been characterized. They constitute one of the largest families of gene regulators that are found in plants and animals. They form a complex network and have key roles in diverse regulatory pathways involved in human health and disease. In this review, different types of ncRNAs, their biogenesis, structure, function and evolutionary significance is showcased