干细胞研究与治疗杂志

抽象的

Non-Motor Symptoms in Parkinsons Disease and Efficacy of Treatment in a Complex Therapy Using Fetal Stem Cells

AA Sinelnyk, NS Sych, MO Klunnyk, MP Demchuk, OV Ivankova, IG Matiyashchuk, MV Skalozub and KI Sorochynska

Aim: To evaluate the dynamics of non-motor symptoms (NMS) by scores in the patients with Parkinson’s disease during complex treatment using fetal stem cells (FSCs) obtained from human fetuses with 5-10 weeks of gestation.

Materials and methods: A comparative study for 63 patients with Parkinson’s disease (PD) suffering from NMS with various degree of clinical presentation has been performed to identify the effect of combined treatment on the quality of life, cognitive functions, sleep and extent of depressive disorders in patients. The main group (MG) consisted of 32 patients, who apart from standard therapy underwent treatment using suspensions of FSCs harvested from the fetal liver and brain. The control group (CG) included 31 patients. The patients in both groups have been compared according to their sex and age.

Results: Significant decrease of NMS in patients of the MG was reported 6 and 12 months after treatment. This value was significantly lower compared to the patients in the CG. By means of a detailed evaluation, significant improvement in quality of the objective parameters of sleep, daily activities and decrease of depressive disorders were reported in the MG. The treatment results were significantly higher in the MG if compared to those in the CG over 1 year after therapy.

Conclusion: FSCs therapy proved to induce positive effects on both subjective and objective manifestations of PD by improving the patient’s quality of life when included into the standard scheme of treatment for PD patients with developed NMS.