药物基因组学和药物蛋白质组学杂志

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Pharmacogenomics- Personalized Treatment of Cancer, Diabetes and Cardiovascular Diseases

Nishant Toomula, Hima Bindu K, Sathish Kumar D and Arun Kumar R

Pharmacogenomics is the study of genetic variations between individuals to predict the risk of toxic side effects and the probability that a patient will respond to single or multiple drug treatment. The ways people respond to drugs are complex traits that are influenced by many different genes. Pharmacogenomics intends to develop rational means of optimizing drug therapy, with respect to the patients’ genotype, to maximize efficacy with minimal adverse drug reactions. Pharmacogenomics has the potential to revolutionize the practice of medicine, and promises to guide in an area of personalized medicine, in which drugs and drug combinations are optimized for each individual’s unique genetic makeup. This review gives information regarding principles of pharmacogenomics and how pharmacogenomics can advance the development of personalized treatments by revealing genetic variations that predict individual responses to therapeutic interventions.