药物分析学报

抽象的

Preformulation

Sousa e Silva JP

A square wave voltammetry (SWV) method for the determination of trace amounts of paracetamol at carbon paste electrode modified with managanese (Mn-CPE) is proposed. The results showed that the Mn-CPE exhibited excellent electro catalytic activity to paracetamol. A quasi-reversible redox process of paracetamol at the modified electrode was obtained. The concentration of paracetamol and measuring solution pH was investigated. This electrochemical sensor shows an excellent performance for detecting paracetamol with a detection limit of 6.8�10-10 mol.L-1 with the relative standard deviation of 2.0% (n=7). The sensor was successfully applied to the determination of paracetamol in a real sample tablets with satisfactory results.