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Reverse Vaccinology: Basics and Applications

Mohamed L Elsaie

Vaccinomics is a new branch of bioinformatics that deals with designing a candidate vaccine against a pathogen that can be used for production of the vaccine in less time as that of conventional vaccinology. Reverse vaccinology is a part of vaccinomics which starts with the genome of pathogen and is used for the predicting the epitope. Epitope prediction is the heart of reverse vaccinology. Reverse vaccinology was used for designing vaccines against some diseases eg. Malaria, Anthrax, Endocarditis, Meningitidis etc. Some approaches against viruses have also been done by reverse vaccinology.