血栓与循环杂志：开放获取

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Rickettsiosis and Coronary Artery Disease: Is The Association Atherosclerosis and Rickettsiosis Fortuitous?

Scadi Soukaina, Mohamed Yassine Benzha, Bensahi Ilham,Ncho Mottoh Marie-Paule, Laarje Aziza,El ouarradi Amal,Oualim Sara,Abdeladim Salma, El Harras Mahassine, Benyoussef Hicham, Makani Said and Sabry Mohamed

Rickettsial infection can affect multiple organs. Heart involvement is rare, although cases of acute myocarditis, pericarditis, advanced atrioventricular block have been reported. We report 2 cases of Rickettsia related to myocardial injury. The first case concerns a 65-year-old patient with minimal atherosclerotic risk factors, who had rickettsiosis one month before admission and who presents with silent myocardial ischemia revealed by a positive stress test, coronary angiogram showed a sub-occlusive stenosis of left anterior descending artery (LAD) with successful recanalization by implantation of one drug-eluting stent. The second one is 71-year-old patient treated for rickettsiosis. He was admitted to our department with Non-ST elevation myocardial infarction, coronary angiogram showed severe calcified triple vessel disease, he had a successful surgical revascularization.Through our observations, we will discuss the physio pathological mechanisms of coronary involvement by Rickettsiosis which would cause vasculopathy by endothelial cell damage.