单细胞生物学

抽象的

R-Spondin 1 Regulates WNT Signaling Pathway by Antagonizing the Function of Dickkopf Homolog 1

Yang Wang, Bingqiang Zhang and Wei Zou

The WNT family of secreted proteins play important roles in diverse biological processes, including development, proliferation, and differentiation, which regulate various diseases, such as prostate cancer, breast cancer, glioblastoma, type II diabetes and others. The WNT ligands could activate two major intracellular pathways: known as the canonical pathway which is β-catenin-dependent, and non-canonical pathway which is β-catenin-independent.