干细胞研究与治疗杂志

抽象的

Stem Cell Therapy Target EMT Process in Glioma

Yu-bao Lu, Tian-jiao Sun, Jia-yu Zhao, Jiang-dong Wang, Feng Miao, Shi-xin Wang

Glioma is one of the most common tumors in the nervous system. It's initiation, migration and the multipotency are effected by cancer stem cell ’s transition. A previous study implies that through change how cancer stem cell performs can affect the malignant differentiation of the tumor. We found some treatments target the regulatory pathways related to Epithelial To Mesenchymal Transition (EMT) of the tumor. In this review, we discuss the transition factor of EMT and three specific pathways which affect EMT of cancer stem cell to affect tumor development. Suggesting that targeting EMT of cancer stem cells can be a feasible pathway of cancer treatment.