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Synthesis and Characterization of α,α-Dimethyl-4-[1-Hydroxy-4-[4-(Hydroxyldiphenyl- Methyl)-1-Piperidinyl]Butyl] Benzeneacetic Acid Metal Complexes of Biological Interest

Saeed M Arayne, Najma Sultana, Hina Shehnaz and Amir Haider

α,α-Dimethyl-4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]benzene acetic acid generically known as fexofenadine or carboxyterfenadine is a second generation H1-receptor antagonist, much widely used due to its non-sedative effects. Metal complexes of fexofenadine with various essential and trace elements of biological interest, have been synthesized and characterized by FT-IR, 1H-NMR, UV, CHN elemental analysis. Conductometric titration was carried out to determine the mole ratio of interaction of the drug and metal. Spectral data clearly showed the complexation of fexofenadine with nitrogen of the piperidine ring in case of magnesium, calcium, chromium and manganese complexes while oxygen of carboxylato group is involved in complexation with iron, cobalt nickel, copper, zinc and cadmium. Elemental analysis reveals monodentate character of these complexes.