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Synthesis of Nano Sulfur Particles and their Antitumor Activity
Faten Z, Mustafa H and Muayad ALD
Objectives: The present study is designed to evaluate the antitumor activity of sulphur containing compounds in Nano formulations against Ehrlisch Ascites Carcinoma (EAC) in female albino mice.
Methods: Preparation of sulfur nanoparticles (S-NPs) was done throughout. Firstly, the evaluation of their composition and purity by fourier transform infrared spectrometer (FT-IR) analysis. Secondly, the shape and size of S-NPs were investigated by scanning electron microscopy (SEM) techniques in all S-NPs samples which were prepared with Tetramethylammoniumbromide (TMAB) surfactant, Then, Energy-dispersive X-ray spectroscopy (EDS) for the evaluation of their composition and purity, after that the X-Ray diffraction patterns were measured for prepared S-NPs with TMAB surfactant, and the determination of S-NPs antitumor activity against (breast carcinoma cell line (MCF7), liver carcinoma cell line (HEPG2), colon carcinoma cell line (HCT116), prostatic carcinoma cell line (PC3). Finally, determination biochemical assay of S-NPs by using female mice bearing EAC and of the assessment of liver functions and evaluation of kidney functions and determination of some heart functions in serum and hematology markers.
Results: This study revealed that S-NPs showed high strong activities in concentration (5 mg/kg) as it improvement of liver functions production compared to the positive control group, also showed the effect of S-NPs of the kidney functions, heart functions and hematology parameters in all studied groups and a significant increase in activities compared with positive control group.
Conclusion: S-NPs play an important role in improving liver functions, kidney functions and the heart functions of resulted in significantly increase activity against tumour and plays an important role in improving oxidative stress resulted in high antiproliferation activity against (MCF-7, HepG2, HCT116 and PC3) cell lines, and significantly increase with S-NPs reduced most of the hematological parameters towards the best compared to the positive control group.