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The Association of Dyslipidemia and Peripheral Diabetic Neuropathy: The Influence of Urea

Patrícia Carvalho Machado Aguiar, Marcus Vinícius Della Coletta and Jean Jorge Silva de Souza

Peripheral neuropathy is a common complication of diabetes mellitus. In the EURODIAB study, total cholesterol and triglycerides were associated to peripheral diabetic neuropathy (PDN). The study’s aim was to evaluate the influence of cholesterol, triglycerides and statin use on a clinical score of peripheral neuropathy in patients with diabetes mellitus. Ninety patients at a university hospital in Manaus, Brazil were included in this study. They were evaluated using Michigan Neuropathy Screening Instrument (MNSI) and the clinical component of the Michigan Diabetic Neuropathy Score (MDNS). According to MDNS clinical component, 20 (22.2%) patients had PDN and compared to those patients who did not have PDN, they had more time of diabetes diagnosis (16.2 ± 11.3 vs. 10.2 ± 8.6 years), more stroke (15 vs. 3%), more insulin use (75.0 vs. 48.6%) and also higher serum urea levels. When considering only the 65 (72.2%) patients with serum urea below 50 mg/dl, there was a positive correlation between total cholesterol and MDNS (r=0.2580, p