衰老科学杂志

抽象的

The Multisystemic origins of Alzheimer’s disease

Ewing GW, SH Parvez

The author discusses the fundamental relationship which exists between sense perception, brain function, and changes of molecular biology and uses Grakov’s mathematical model of the relationship between sense perception, brain function, the autonomic nervous system and physiological systems, and cellular and molecular biology to explain this complex relationship in the Alzheimer patient.

This paper illustrates that changes of molecular biology (the a-Beta amyloid protein and fibrils) are the consequence of the failure of the brain to optimise the function of the physiological systems, in particular sleep, posture, intercellular pH and blood glucose.

It is shown that Alzheimer’s Disease is a polygenomic, multisystemic and multi-pathological indication, with cognitive and neurological origins, and that knowledge of this mechanism has the potential to screen and treat the autonomic dysfunction which characterizes Alzheimer’s Disease and all common pathologies.

Case studies of how the technology can be used to screen the Alzheimer patient, and to treat a wide range of cognitive and/or pathological indications, are used to support the presented arguments.