生物等效性和生物利用度杂志

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UV Spectrophotometric Method for Estimation of Ofloxacin in Tablet Dosage Form and Comparative Study of its Two Brands

Safila Naveed, Tanweer Alam, Asra Hameed and Neelam Sharif

Ofloxacin is used to treat a bacterial infection. It is indicated for the treatment of adults with mild to moderate infections triggered by susceptible strains of the nominated microorganisms in the infections likes acute bacterial exacerbations of chronic bronchitis, community acquired pneumonia, uncomplicated skin and skin structure infections, acute, uncomplicated urethral and cervical gonorrhea, nongonococcal urethiritis and cervicitis, mixed infections of the urethra and cervix, acute pelvic inflammatory disease (including severe infection), uncomplicated cystitis, complicated urinary tract infections and prostatitis. The most common side-effects are feeling sick, diarrhea, feeling dizzy and headache. Spectrophotometry is regarded as by its speed and simplicity, accuracy and inexpensive instrument needed, and hence it is a significant substitute to further analytical methods, through clear advantages in terms of cost of analysis. Assay of Ofloxacin tablets is carried out by a rapid, simple, accurate, and economical least time consuming spectrophotometric method and then compares it with the assay of two different brands available in Karachi, Pakistan. Results of assay reveal that both trademarks of Ofloxacin are bioequivalent and are within the endorsed range. Brand A shows a percent assay of 100% while Brand B shows low value for percentage assay that is 96.31%.